Human Pancreatic Stellate Cells
Catalog #3830
Human Pancreatic Stellate Cells is a new cell product offered by ScienCell, and is also just identified in the pancreas in the recent decade. Pancreatic stellate cells reside in the exocrine area of pancreas and surround the pancreatic acinar cells and pancreatic ducts. They are regulated by paracrine and autocrine stimuli, and can switch between quiescent and activated states. When primary pancreatic stellate cells are cultured, they become activated to acquire myofibroblast-like morphology and secret extracellular matrix proteins. In pancreas, quiescent pancreatic stellate cells are activated as a consequence of pancreatic injury. They are induced to proliferate, migrate to the sites of injury and secret extracellular matrix proteins to promote tissue repair. However, persistent activation of pancreatic stellate cells can lead to fibrosis that is associated with chronic pancreatitis and pancreatic cancer. In recent years, they have become potential therapeutic targets for the treatment and prevention of these diseases.
